“How can one fit 2 meters of DNA inside the nucleus of a cell?”

“Simple! You just need to fold it in the right way”

The Tao of the genome

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Our laboratory is interested in this beautiful but complex question. In other words, we seek to understand gene regulation in the context of a 3D genome. Using in vivo models, we aim to decipher how cellular fate is determined and maintained and how this information is encoded in vertebrate genomes (learn more here).

Our methodology employs approaches to map 3D chromatin structures and regulatory elements, as well as cutting-edge genome editing technologies. This combination of methods allows us to define 3D regulatory landscapes with accuracy and assess their functionality in vivo (learn more here).